Fig. 2.

Three-Tesla magnetic resonance images (MRIs) of patient 2 (a, b) and her sister (c). Coronal 3D time-of flight (TOF) MRA maximum intensity projection (MIP) (a) image of patient at the age of 15 years demonstrates (near) occlusion of the M1 segment of the right middle cerebral artery (thick arrow) and the A1 segment of the right anterior cerebral artery (long arrow), and severe stenosis of the M1 segment of the left middle cerebral artery (thick arrow) and the A1 segment of the left anterior cerebral artery (long arrow). Axial fluid-attenuated inversion recovery (FLAIR) MRI (b) of the patient at the age of 17 years shows infarct in right middle and anterior cerebral arteries. Coronal 3D TOF MRA MIP image (c) of the sister of patient 2 at the age of 14 years shows normal appearance of intracranial arteries. Basilar artery and side branches were manually removed from the 3D data sets in a and c to better demonstrate the anterior cerebral arteries