Figure 4. Discordance Associated Mutations (DAMs) within HIV-1PR alters the generation of caspase 3.

YFP HIV protease or the indicated protease point mutants were expressed in HeLa cells, and the YFP positive cells were analyzed for percent active caspase 3 positive (A, B), and total caspase 3 activity (C). *Indicates p value ≤0.05. Data reflective of at least three independent replicates. Bars with solid color represent controls, bars with angled hatching represent DAMs, and bars with horizontal hatching represent non-DAMs.