Figure 7. Reduced HIV-1PR-induced cell death is associated with reduced Casp8p41 production.

YFP HIV protease or the indicated protease mutants were expressed in primary CD4 T cells and YFP positive cells were analyzed for Casp8p41 positivity (A, B). *Indicates p value ≤0.05. Data reflective of at least three independent replicates. Bars with solid color represent controls, bars with angled hatching represent Discordance Associated Mutations (DAMs), and bars with horizontal hatching represent non-DAMs.