Figure 9. HXB2 HIV containing Discordance Associated Mutations (DAMs) are associated with impaired killing of primary CD4 T cells.

Primary CD4 T cells were infected with HXB2 containing wild-type HIV protease, or protease containing the mutations L90M, I54V, or V82A, and analyzed for (A) cell viability by ATP production, (B) P24 production, and (C) TUNEL positivity in the infected (P24 +), or (D) uninfected (P24-) subsets.