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. 2010 Nov 24;6(11):e1001205. doi: 10.1371/journal.ppat.1001205

Figure 6. tHRF is required for tick rapid feeding.

Figure 6

Quantitative RT-PCR assessment of the expression pattern of: (A) tick histamine binding protein 1 (HBP1), (B) HBP2, (C) HBP3 and (D) tick histamine release factor (tHRF). (E) Weights of ticks at 72 h post tick attachment on mice treated with histamine (10mM) or PBS (control). (F) Weights of ticks at 72 h post tick attachment on mice treated with recombinant tHRF (10µg) or GST (control). (G) B. burgdorferi burden in ticks fed on mice treated with recombinant tHRF (10µg) or GST (control). Horizontal lines and bars represent the mean values ± the SEM. * p<0.05 and ** p<0.01. Representative results from at least 3 independent experiments were shown.