Table 4.
Pearson correlation coefficient of ln(ic50) for pairs of MHC-I and MHC-II alleles.
| MHC-I | MHC-II | |||||
|---|---|---|---|---|---|---|
| Top Ten | HLA 1 | HLA 2 | r | HLA 1 | HLA 2 | r |
| A*2402 | A*2301 | 0.67 | DRB4*0101 | DRB1*0404 | 0.63 | |
| B*4403 | B*4402 | 0.60 | DRB1*0701 | DRB1*0404 | 0.63 | |
| A*2403 | A*2301 | 0.54 | DRB1*1501 | DRB1*0404 | 0.62 | |
| B*4403 | B*4002 | 0.51 | DRB1*0405 | DRB1*0404 | 0.58 | |
| B*4501 | B*4403 | 0.50 | DRB1*1101 | DRB1*0404 | 0.55 | |
| A*2403 | A*2402 | 0.49 | DRB1*1501 | DRB1*0701 | 0.54 | |
| B*4403 | B*1801 | 0.47 | DRB5*0101 | DRB1*1101 | 0.53 | |
| B*4501 | B*4002 | 0.45 | DRB4*0101 | DRB1*1501 | 0.52 | |
| B*5301 | B*5101 | 0.41 | DRB5*0101 | DRB1*0404 | 0.52 | |
| B*5301 | A*2402 | 0.40 | DRB1*1101 | DRB1*0802 | 0.51 | |
| Bottom Ten | B*5701 | B*1801 | -0.26 | DRB3*0101 | DRB1*0405 | 0.23 |
| B*4501 | A*2601 | -0.26 | DRB1*1302 | DRB1*0405 | 0.23 | |
| B*5701 | B*5401 | -0.27 | DRB1*1302 | DRB1*1101 | 0.23 | |
| A*3002 | A*2301 | -0.28 | DRB1*0901 | DRB1*0301 | 0.22 | |
| B*4501 | A*6801 | -0.29 | DRB3*0101 | DRB1*0101 | 0.22 | |
| B*4403 | A*3002 | -0.29 | DRB1*0802 | DRB1*0301 | 0.21 | |
| B*4002 | A*6801 | -0.31 | DRB3*0101 | DRB1*1101 | 0.20 | |
| B*4402 | A*2902 | -0.31 | DRB5*0101 | DRB3*0101 | 0.20 | |
| B*4501 | A*2301 | -0.32 | DRB1*0301 | DRB1*0101 | 0.20 | |
| B*4403 | A*2902 | -0.34 | DRB3*0101 | DRB1*0802 | 0.19 | |
| B*4002 | A*3002 | -0.46 | DRB3*0101 | DRB1*0901 | 0.15 | |
The Pearson correlation coefficients were computed for all allele combinations on a random sample of 1000 15-mers (MHC-II) and 1000 9-mers (MHC-I) from the Staphylococcus aureus COL dataset. All coefficients are significant p < 0.0001. Note that for MHC-I there are both negative and positively correlated pairs. Some of the coefficients ~0.0 were not statistically significant in this case.