Table 3.
Significant associations of candidate gene polymorphisms and albumin-to-creatinine ratioa, additive genetic model
| Crude Model | Fully Adjustedb Model | |||||
|---|---|---|---|---|---|---|
| Variant | β coefficient (95% CI) | P-value | FDR-adjusted P-value | β coefficient (95% CI) | P-value | FDR-adjusted P-value |
| Non-Hispanic whites | ||||||
| rs1801274 (FCGR2A) | 0.07 (-0.01-0.14) | 0.0884 | 0.7950 | 0.09 (0.01-0.17) | 0.0308 | 0.5610 |
| rs1800790 (FGB) | -0.07 (-0.15-0.01) | 0.0854 | 0.7950 | -0.08 (-0.17--0.00) | 0.0417 | 0.5610 |
| rs11003125 (MBL2) | 0.10 (0.03-0.17) | 0.0058 | 0.1300 | 0.09 (0.02-0.15) | 0.0131 | 0.3930 |
| rs9282799 (NOS2A) | 1.31 (0.58-2.04) | 0.0011 | 0.0660 | 0.81 (0.00-1.62) | 0.0490 | 0.5610 |
| rs1800750 (TNF) | 0.41 (0.13-0.70) | 0.0065 | 0.1300 | 0.35 (0.09-0.60) | 0.0092 | 0.3930 |
| Non-Hispanic blacks | ||||||
| rs1205 (CRP) | -0.11 (-0.25-0.04) | 0.1441 | 0.7663 | -0.15 (-0.29--0.00) | 0.0441 | 0.5471 |
| rs1799963 (F2) | -0.88 (-2.20-0.44) | 0.1810 | 0.7663 | -0.96 (-1.88--0.04) | 0.0411 | 0.5471 |
| rs1800468 (TGFB1/B9D2) | -0.34 (-0.65--0.03) | 0.0328 | 0.7663 | -0.33 (-0.70-0.04) | 0.0750 | 0.5471 |
| Mexican Americans | ||||||
| rs1800482 (NOS2A) | -0.06 (-0.69-0.57) | 0.8458 | 0.9877 | -0.32 (-0.58--0.06) | 0.0176 | 0.3520 |
| rs9282799 (NOS2A) | 0.67 (0.29-1.05) | 0.0014 | 0.0840 | 0.58 (-0.44-1.59) | 0.2513 | 0.9466 |
| rs1799983 (NOS3) | -0.12 (-0.30-0.06) | 0.1699 | 0.8693 | -0.18 (-0.32--0.04) | 0.0145 | 0.3520 |
| rs1799762 (SERPINE1) | 0.10 (0.01-0.19) | 0.0295 | 0.5900 | 0.03 (-0.07-0.12) | 0.5637 | 0.9466 |
CI, confidence interval; FDR, false-discovery rate.
a) Defined as log-transformed albumin-to-creatinine ratio (ACR) and analyzed as a continuous variable. b) Analyses adjusted for age, sex, alcohol consumption, educational attainment, and waist:hip ratio.