Table 5.
Significant associations of candidate gene polymorphisms and single-threshold albuminuriaa, additive genetic model
| Crude Model | Fully Adjustedb Model | |||||
|---|---|---|---|---|---|---|
| Variant | OR (95% CI) | P-value | FDR-adjusted P-value | OR (95% CI) | P-value | FDR-adjusted P-value |
| Non-Hispanic whites | ||||||
| rs1260326 (GCKR) | 1.19 (0.92-1.53) | 0.1774 | 0.8886 | 1.29 (1.02-1.64) | 0.0361 | 0.6200 |
| rs1800750 (TNF) | 3.20 (2.06-4.98) | < 0.0001 | < 0.0001 | 3.60 (1.65-7.88) | 0.0025 | 0.1500 |
| rs361525 (TNF) | 1.71 (1.18-2.47) | 0.0060 | 0.1800 | 1.94 (1.17-3.22) | 0.0128 | 0.3840 |
| rs2239185 (VDR) | 0.81 (0.67-0.97) | 0.0246 | 0.4020 | 0.84 (0.70-1.02) | 0.0817 | 0.6200 |
| rs731236 (VDR) | 1.31 (1.03-1.65) | 0.0268 | 0.4020 | 1.26 (0.99-1.61) | 0.0612 | 0.6200 |
| Non-Hispanic blacks | ||||||
| rs1205 (CRP) | 0.75 (0.60-0.95) | 0.0195 | 0.5655 | 0.74 (0.56-0.98) | 0.0394 | 0.7760 |
| rs3093058 (CRP) | 0.74 (0.54-1.01) | 0.0584 | 0.5942 | 0.72 (0.52-0.99) | 0.0466 | 0.7760 |
| rs1800468 (TGFB1/B9D2) | 0.22 (0.06-0.76) | 0.0193 | 0.5655 | 0.12 (0.01-0.99) | 0.0493 | 0.7760 |
| Mexican Americans | ||||||
| rs1800947 (CRP) | 0.37 (0.08-1.77) | 0.2022 | 0.6802 | 0.08 (0.03-0.20) | < 0.0001 | < 0.0001 |
| rs1143623 (IL1B) | 1.30 (1.06-1.60) | 0.0149 | 0.4321 | 1.55 (1.28-1.87) | 0.0001 | 0.0029 |
| rs1800871 (IL10) | 1.24 (1.02-1.51) | 0.0361 | 0.5234 | 1.14 (0.84-1.55) | 0.3759 | 0.9181 |
| rs1800872 (IL10) | 1.25 (1.03-1.52) | 0.0290 | 0.5234 | 1.15 (0.84-1.56) | 0.3630 | 0.9181 |
| rs1799983 (NOS3) | 0.65 (0.39-1.10) | 0.1046 | 0.6067 | 0.60 (0.37-0.98) | 0.0423 | 0.4089 |
| rs2070744 (NOS3) | 0.66 (0.51-0.85) | 0.0028 | 0.1624 | 0.62 (0.48-0.80) | 0.0008 | 0.0155 |
| rs1800629 (TNF) | 0.75 (0.45-1.27) | 0.2729 | 0.6914 | 0.65 (0.43-0.98) | 0.0414 | 0.4089 |
CI, confidence interval; FDR, false-discovery rate; OR, odds ratio.
a) Defined as urinary albumin-to-creatinine ratio (ACR) above ≥ 30 mg/g regardless of gender. b) Analyses adjusted for age, sex, alcohol consumption, educational attainment, and waist:hip ratio.