Table 1. TSHR genotype and allele frequencies in Warsaw, Gliwice, combined Polish cohorts and UK case-control cohorts.
| TSHR SNP | Cohort | Alleles/Genotypes | Controls (%) | GD (%) | P | OR | 95% CI |
| rs179247: | Warsaw | AA | 81 (15.6) | 139 (24.9) | 2.0×10−4 | 1.42 | 1.20–1.68 |
| AG | 259 (49.0) | 270 (48.8) | |||||
| GG | 180 (34.6) | 149 (26.7) | |||||
| A | 421 (40.5) | 548 (49.1) | 6.0×10−5 | ||||
| G | 619 (59.5) | 568 (50.9) | |||||
| Gliwice | AA | 34 (17.1) | 58 (29.6) | 1.2×10−2 | 1.45 | 1.10–1.93 | |
| AG | 98 (49.2) | 84 (42.9) | |||||
| GG | 67 (33.7) | 54 (27.6) | |||||
| A | 166 (41.7) | 200 (51.0) | 9.0×10−3 | ||||
| G | 232 (58.3) | 192 (49.0) | |||||
| Polish Cohorts Pooled | AA | 115 (16.0) | 197 (26.1) | 3.0×10−6 | 1.43 | 1.23–1.65 | |
| AG | 356 (49.7) | 354 (46.9) | |||||
| GG | 247 (34.4) | 203 (26.9) | |||||
| A | 586 (40.8) | 748 (49.6) | 2.0×10−6 | ||||
| G | 850 (59.2) | 760 (50.4) | |||||
| UK GD National Collection | AA | 737 (29.0) | 879 (37.6) | 8.6×10−14 | 1.38 | 1.27–1.49 | |
| AG | 1243 (48.9) | 1110 (47.4) | |||||
| GG | 561 (22.1) | 351 (15.0) | |||||
| A | 2717 (53.5) | 2868 (61.3) | 6.2×10−15 | ||||
| G | 2365 (46.5) | 1812 (38.7) | |||||
| rs12101255: | Warsaw | TT | 35 (6.7) | 75 (13.4) | 1.0×10−4 | 1.47 | 1.23–1.77 |
| TC | 212 (40.8) | 245 (43.9) | |||||
| CC | 273 (52.5) | 238 (42.7) | |||||
| T | 282 (27.1) | 395 (35.4) | 3.0×10−5 | ||||
| C | 758 (72.9) | 721 (64.6) | |||||
| Gliwice | TT | 17 (8.6) | 32 (16.3) | 2.0×10−4 | 1.87 | 1.39–2.53 | |
| TC | 71 (35.9) | 94 (48.0) | |||||
| CC | 110 (55.6) | 70 (35.7) | |||||
| T | 105 (26.5) | 158 (40.3) | 4.0×10−5 | ||||
| C | 291 (73.5) | 234 (59.7) | |||||
| Polish Cohorts Pooled | TT | 52 (7.2) | 107 (14.2) | 1.0×10−7 | 1.57 | 1.34–1.84 | |
| TC | 283 (39.4) | 339 (45.0) | |||||
| CC | 383 (53.3) | 308 (40.8) | |||||
| T | 387 (27.0) | 553 (36.7) | 2.0×10−8 | ||||
| C | 1049 (73.1) | 955 (63.3) | |||||
| UK GD National Collection | TT | 338 (13.4) | 482 (20.9) | 4.14×10−20 | 1.49 | 1.37–1.61 | |
| TC | 1148 (45.3) | 1136 (49.3) | |||||
| CC | 1046 (41.3) | 687 (29.8) | |||||
| T | 1824 (36.0) | 2100 (45.6) | 3.68×10−21 | ||||
| C | 3240 (64.0) | 2510 (54.4) |
Both SNPs are displayed 5′ – 3′ on the positive DNA strand. P-values generated via chi-squared (χ2) tests for both alleles (2×2) and genotypes (co-dominant) are displayed. The odds ratios (ORs) and 95% CI have been calculated from the minor allele in each SNP.