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. Author manuscript; available in PMC: 2011 Oct 30.
Published in final edited form as: Adv Drug Deliv Rev. 2010 Aug 17;62(13):1218–1226. doi: 10.1016/j.addr.2010.08.007

Fig. 1. Domain organization of nuclear receptors.

Fig. 1

A, A schematic representation showing functional domains of different nuclear receptors. The DBD is labeled in blue, the hinge is in green and the LBD is in yellow. The presence of AF-2 is indicated in red. B, Multi-domain structure of the PPARγ/RXR/DNA complex in ribbon representation. The crystal structures of PPARγ(blue) and RXRα(green) heterodimer (top) on PPAR response DNA sequence (Bottom).