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. Author manuscript; available in PMC: 2011 Oct 30.
Published in final edited form as: Adv Drug Deliv Rev. 2010 Aug 11;62(13):1299–1306. doi: 10.1016/j.addr.2010.08.003

Figure 2.

Figure 2

The TLX-microRNA regulatory loop in neural stem cells (NSC). (A) NSC self-renewal is maintained by TLX through its repression of the expression of miR-9 pri-miRNA (pri-miR-9). (B) Under differentiation conditions, TLX protein is decreased, which leads to de-repression of miR-9 expression. miR-9 then binds to TLX mRNA and leads to further inhibition of TLX expression, through either TLX mRNA degradation or TLX translational inhibition. The TLX-miR-9 regulatory loop in turn induces differentiation of neural stem cells into neurons and glia.