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. Author manuscript; available in PMC: 2011 Dec 29.
Published in final edited form as: Neuroscience. 2010 Oct 1;171(4):1197–1208. doi: 10.1016/j.neuroscience.2010.09.059

Figure 1. Comparison of stress-related neuroendocrine factors in BTBR versus B6 mice.

Figure 1

Plasma levels of corticosterone, corticotrophin releasing factor (CRF) and oxytocin were determined by radioimmunoassay. Glucocorticoid receptor (GR) mRNA was determined by in situ hybridization. (A) Plasma corticosterone levels were higher in BTBR than B6, **p<0.01. N=12 BTBR, N=12 B6. (B) CRF detected in the paraventricular nucleus of the hypothalamus (PVN) did not differ between BTBR and B6. N=10 BTBR, N=9 B6. (C) GR mRNA measured by optical density units in the CA1 region of the hippocampus was significantly higher in BTBR than B6, *p<0.05. N=5 BTBR, N=5 B6. (D) Oxytocin peptide levels in the PVN were significantly higher in BTBR than B6, **p<0.01. N=9 BTBR, N=10 B6. Data are shown as ± SEM in all Figures.