. Author manuscript; available in PMC: 2012 Jan 1.

Published in final edited form as: Biochem Pharmacol. 2010 Oct 30;81(1):1–5. doi: 10.1016/j.bcp.2010.09.018

TABLE 1.

LRP1 known ligands

Proteins involved in lipoprotein metabolism

Apolipoprotein E-enriched lipoproteins (chylomicron and VLDL remnants), Lipoprotein lipase (LPL), Hepatic lipase, Sphingolipid activator protein

Proteases and protease/inhibitor complexes

Activated α₂-macroglobulin, α₂-macroglobulin protease complexes, Pregnancy zone protein-protease complexes, Aprotinin, urokinase plasminogen activator (uPA), pro- uPA, plasminogen activator inhibitor (PAI-1), uPA/PAI-1 complexes, tissue-type plasminogen activator (tPA), tPA/PAI-1 complexes, Thrombin/PA-1, Thrombin/anti- thrombin III, Thrombin/protease nexin-1, Thrombin/heparin cofactor II, Neuroserpin, Neuroserpin/tPA complexes, C1s/C1q inhibitor, Protease/protein C inhibitor, Elastase/α₁-anti-trypsin, MMP-9, MMP-13, TSP-2/MMP-2 complexes, Tissue factor pathway inhibitor (TFPI), Factor VIIa/TFPI, Factor VIIIa, Factor IXa, Factor IXa/protease nexin-1, β-amyloid precursor protein

Matrix proteins

Thrombospondin-1, Thrombospondin-2, Fibronectin

Intracellular proteins

Receptor associated protein (RAP), Calreticulin, HIV Tat protein

Growth factors

Platelet-derived growth factor (PDGF), Midkine, Insulin-like growth factor (IGF)- binding protein-3 (IGFBP-3), Connective tissue growth factor (CTGF/CCN2), Transforming growth factor (TGF-β)

Others

Circumsporozoite protein, Lactoferrin, Ricin A, Saposin, Rhinovirus A peptide (monomer), Gentamicin, Polymycin B, Pseudomonas exotoxin A, Complement C3, Collectins (via calreticulin)