Table 2.
Comparison of the observed cancer incidence in the MACS to the expected cancer incidence based on data from the SEER Program by HIV status (1984–2007).
| HIV Negative | HIV Positive | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cancer | SEER Cancer Site Recodes for ICD-O-3 |
Obs | Exp | SIR | Exact 95% CI | Obs | Exp | SIR | Exact 95% CI | |
| Oral cavity/pharynx | 20010–20100 | 3 | 6.8 | 0.44 | (0.09, 1.29) | 5 | 3.6 | 1.38 | (0.45, 3.23) | |
| Colon | 21041–21049 | 3 | 10.0 | 0.30 | (0.06, 0.87) | 1 | 4.6 | 0.22 | (0.006, 1.22) | |
| Rectum | 21051, 21052 | 4 | 5.5 | 0.72 | (0.20, 1.85) | 3 | 2.6 | 1.13 | (0.23, 3.31) | |
| Anus | 21060 | 2 | 0.8 | 2.50 | (0.30, 9.03) | 15 | 0.6 | 25.71 | (14.39, 42.40) | |
| Liver | 21071 | 2 | 2.2 | 0.91 | (0.11, 3.28) | 3 | 1.4 | 2.17 | (0.45, 6.34) | |
| Pancreas | 21100 | 2 | 3.2 | 0.63 | (0.08, 2.29) | 2 | 1.5 | 1.37 | (0.17, 4.95) | |
| Other digestive systems | 21010–21130 (except 21041– 21071, 21100) |
3 | 6.7 | 0.45 | (0.09, 1.31) | 2 | 3.3 | 0.61 | (0.07, 2.20) | |
| Lung | 22030 | 6 | 19.7 | 0.30 | (0.11, 0.66) | 9 | 8.3 | 1.09 | (0.50, 2.07) | |
| Other respiratory | 22010, 22020, 22050, 22060 | 3 | 3.1 | 0.98 | (0.20, 2.87) | 2 | 1.5 | 1.35 | (0.16, 4.89) | |
| Bones and joints | 23000 | 0 | 0.4 | 0 | (0, 9.87) | 1 | 0.2 | 4.09 | (0.10, 22.80) | |
| Soft tissues | 24000 | 2 | 1.2 | 1.63 | (0.20, 5.90) | 0 | 0.8 | 0 | (0, 4.78) | |
| Melanoma | 25010 | 7 | 14.1 | 0.50 | (0.20, 1.03) | 9 | 7.3 | 1.23 | (0.56, 2.34) | |
| Other skin | 25020 | 1 | 0.6 | 1.55 | (0.04, 8.63) | 0 | 0.4 | 0 | (0, 9.59) | |
| Prostate | 28010 | 25 | 34.5 | 0.72 | (0.47, 1.07) | 12 | 13.3 | 0.90 | (0.47, 1.57) | |
| Testis | 28020 | 2 | 3.8 | 0.52 | (0.06, 1.89) | 7 | 2.8 | 2.48 | (0.997, 5.11) | |
| Bladder | 29010 | 3 | 8.0 | 0.37 | (0.08, 1.09) | 1 | 3.3 | 0.31 | (0.008, 1.71) | |
| Kidney and renal pelvis | 29020 | 1 | 5.6 | 0.18 | (0.004, 0.99) | 2 | 2.9 | 0.69 | (0.08, 2.47) | |
| Brain | 31010, 31040 | 0 | 3.3 | 0 | (0, 1.11) | 1 | 1.9 | 0.52 | (0.01, 2.89) | |
| Thyroid | 32010 | 2 | 2.2 | 0.92 | (0.11, 3.33) | 1 | 1.4 | 0.73 | (0.02, 4.06) | |
| Other endocrine | 32020 | 0 | 0.3 | 0 | (0, 13.78) | 1 | 0.2 | 5.80 | (0.15, 32.30) | |
| Hodgkin’s lymphoma | 33011, 33012 | 1 | 1.7 | 0.57 | (0.01, 3.19) | 9 | 1.2 | 7.30 | (3.34, 13.85) | |
| Non-Hodgkin’s lymphoma | 33041, 33042 | 6 | 9.0 | 0.66 | (0.24, 1.44) | 194 | 5.3 | 36.80 | (31.80, 42.36) | |
| Myeloma | 34000 | 2 | 1.7 | 1.16 | (0.14, 4.21) | 3 | 0.8 | 3.56 | (0.73, 10.40) | |
| Leukemia | 35011–35043 | 2 | 2.0 | 1.02 | (0.12, 3.68) | 2 | 1.1 | 1.80 | (0.22, 6.52) | |
| Kaposi’s sarcoma 1 | 36020 | 2 | 5.5 | 0.36 | (0.04, 1.31) | 552 | 4.0 | 139.10 | (127.67, 151.14) | |
| Poorly defined cancers | 37000 | 2 | 3.4 | 0.59 | (0.07, 2.13) | 10 | 1.7 | 6.04 | (2.90, 11.11) | |
Abbreviations: Obs: Observed; Exp: Expected; SIR: Standardized incidence ratio; CI: Confidence Interval; ICD-O-3: International classification of diseases for oncology, third edition.
SIRs significantly different from 1 are shown in BOLD.
1
Using the methods of Chaturvedi et al (23), the Kaposi’s sarcoma SIRs (exact 95% CI) were 29.13 (3.53, 105.24) for HIV negative men and 17381.45 (15954.16, 18886.28) for HIV positive men.