Table 3.
Adjusted cancer incidence in the MACS by HIV status.
| Cancer incidence by HIV status adjusted for age and race 1 |
||
|---|---|---|
| Cancer | Adjusted IRR | Exact 95% CI |
| Oral cavity/pharynx | 2.64 | (0.50, 17.30) |
| Colon | 0.77 | (0.01, 10.45) |
| Rectum | 1.25 | (0.17, 7.86) |
| Anus | 13.57 | (3.01, 126.49) |
| Liver | 5.69 | (0.45, 300.36) |
| Pancreas | 2.27 | (0.16, 32.88) |
| Other digestive systems | 1.48 | (0.12, 13.71) |
| Lung 1 | 2.59 | (0.80, 9.02) |
| Other respiratory | 1.18 | (0.10, 10.51) |
| Bones and joints 2 | INF | (0.02, INF) |
| Soft tissues 3 | 0 | (0, 9.74) |
| Melanoma | 2.68 | (0.85, 8.91) |
| Other skin 3 | 0 | (0, 588.74) |
| Prostate | 1.22 | (0.54, 2.60) |
| Testis | 3.97 | (0.74, 39.55) |
| Bladder | 0.61 | (0.01, 7.91) |
| Kidney and renal pelvis | 2.45 | (0.12, 152.88) |
| Brain 2 | INF | (0.03, INF) |
| Thyroid | 0.65 | (0.01, 12.55) |
| Other endocrine 2 | INF | (0.10, INF) |
| Hodgkin’s lymphoma | 13.29 | (1.81, 588.91) |
| Non-Hodgkin’s lymphoma | 48.71 | (21.91, 134.64) |
| Myeloma | 2.11 | (0.22, 27.64) |
| Leukemia | 1.08 | (0.08, 15.32) |
| Kaposi’s sarcoma | 374.73 | (106.67, 3800.54) |
| Poorly defined cancers | 9.53 | (1.97, 91.25) |
Abbreviations:
IRR: Incidence rate ratio
CI: Confidence interval
INF: Infinity
Adjusted IRRs significantly different from 1 are shown in BOLD.
The Poisson regression model for lung cancer was restricted to 4300 men who reported having ever smoked cigarettes, and was adjusted for age, race, and pack-years.
When no incident cancers were observed among the HIV-uninfected group, the IRR calculation involves division by zero and results in an undefined parameter estimate which is represented in this table by INF (infinity). In these cases the upper bound of the exact 95% CI is unbounded.
When no incident cancers were observed among the HIV-infected group, both the IRR and the lower bound of the exact 95% CI are reported as zero.