TABLE.

Ertapenem pharmacokinetic parameters following a single intravenous dose.

Parameter	<2 years (n=41)	2 to 12 years (n=28)	>12 years (n=11)	Adulta (n=67)
Age (yr)	1.0 ± 0.6	6.7 ± 3.4	14.3 ± 0.9	NR
Dose (mg)	241 ± 132	663 ± 442	1331 ± 519	1000
Dose (mg/kg)	25.56 ± 11.49	26.12 ± 10.98	24.58 ± 8.34	14.3
Ceoi (mg/L)	135.2 ± 51.8b	173.1 ± 68.3c	212.0 ± 57.4d	161.5 (145.6–175.3)
Ceoi (mg/L per mg/kg dose)	6.1 ± 2.2b	6.9 ± 2.4c	8.7 ± 1.9d	11.3 (10.2–12.3)
AUC0-∞ (mg*hr/L)	385.8 ± 175.2e	469.8 ± 246.8c	861.3 ± 478.2d	600.6 (572.1–627.3)
AUC0-∞ (mg*hr/L per mg/kg dose)	17.0 ± 5.4e	18.4 ± 8.0c	34.7 ± 14.7d	42.0 (40.0–43.9)
C6 (mg/L)	13.8 ± 4.0f	11.7 ± 10.0g	NP	NR
C6 (mg/L per mg/kg dose)	0.9 ± 0.3f	0.8 ± 0.6g	NP	NR
C12 (mg/L)	3.8 ± 3.0h	5.5 ± 4.2c	10.6 ± 8.2	10.2 (9.3–11.3)
C12 (mg/L per mg/kg dose)	0.2 ± 0.1h	0.2 ± 0.2c	0.4 ± 0.2	0.7 (0.7–0.8)
CL (mL/min/kg)	1.02 ± 0.27e	1.02 ± 0.35c	0.64 ± 0.16d	0.41 (0.38–0.42)
Vss (L/kg)	0.21 ± 0.05e	0.21 ± 0.06c	0.17 ± 0.02d	0.14 (0.13–0.15)
t½ (hr)	2.9 ± 0.7j	3.0 ± 0.9	4.0 ± 0.8	4.0 (3.8–4.4)
λz (1/hr)	0.262 ± 0.094j	0.254 ± 0.092	0.182 ± 0.037	0.176 (0.158–0.182)

^aData are represented as the weighted pooled average (range) for the individual studies reported by Majumdar et al.[17] Weight corrected estimates assume an average adult weight of 70 kg

^bn=40

^cn=27

^dn=10

^en=33

^fn=11

^gn=8

^hn=39

^jn=34

NR- not reported

NP- not performed