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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Trends Biochem Sci. 2010 Aug 21;36(1):39–46. doi: 10.1016/j.tibs.2010.07.009

Figure 2.

Figure 2

Chromatin-bound: SIRT6 regulates multiple chromatin-templated processes. A. SIRT6 deacetylates H3K9 and H3K56 at telomeres, and SIRT6 depletion triggers aberrant telomere metabolism. B. SIRT6 enables efficient DSB repair. C. Although the role of SIRT6 in BER has not been clearly defined, the spectrum of DNA damage sensitivities of Sirt6−/− mouse cells and the results of functional complementation assays suggest a potential chromatin-regulatory function for SIRT6 in this repair pathway. D. SIRT6 represses NF-κB and HIF1α target gene expression, and might act in conjunction with other transcription factors (TFs) to regulate additional gene expression programs. Question marks indicate hypothesized or uncharacterized roles for SIRT6.