. Author manuscript; available in PMC: 2011 Dec 1.

Published in final edited form as: Trends Pharmacol Sci. 2010 Oct 19;31(12):580–586. doi: 10.1016/j.tips.2010.09.004

Table 1.

structures of nicotinic agents that have been used successfully in rodent models of antidepressant efficacy.

Common name	Systematic name (IUPAC)	Structure
Nicotine	3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
Mecamylamine	(2R)-N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine
Cytisine	(1R,5S)- 1,2,3,4,5,6- hexahydro- 1,5-methano-8H- pyrido[1,2a][1,5] diazocin-8-one
3-pyridylyl-cytisine	(1R,5S)-1,2,3,4,5,6-hexahydro-9-(3-pyridinyl)-1,5-methano-8H- pyrido[1,2-a][1,5]diazocin-8-one
5-bromo-cytisine	(1R,5S)-11-bromo-1,2,3,4,5,6-hexahydro-1,5-methano-8H- pyrido[1,2-a][1,5]diazocin-8-one
Varenicline	7,8,9,10-tetrahydro- 6,10-methano- 6H–pyrazino (2,3-h)(3) benzazepine
Sazetidine-A	6-[5-[(2S)-2-Azetidinylmethoxy]-3-pyridinyl]-5-hexyn-1-ol
Isopronicline	(2S,4E)-5-(5-isopropoxypyridin-3-yl)-N-methylpent-4-en-2- amine
PNU-282987	N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide