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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Trends Endocrinol Metab. 2010 Sep 27;21(12):699–706. doi: 10.1016/j.tem.2010.08.008

Figure 3.

Figure 3

miR-33 Reduces Cholesterol Transport And Efflux Under Low Sterol Conditions. When sterol conditions are low, SREBP-2 is cleaved in the Golgi and translocates to the nucleus, where it acts as a transcription factor to regulate genes containing a sterol response element (SRE), including SREBP-2 itself. miR-33a is located within intron 16 of SREBP-2, and is co-transcribed along with its host transcript. Once processed by the miRNA system, mature miR-33a can bind the 3′UTR of its target genes, such as ABCA1, ABCG1 and NPC1 repressing their expression. This results in reduced cholesterol efflux to apoA1 and HDL.