Table 1.
Cholesterol and lipid-related genes regulated by miR-33, miR-122 and miR-370
| miRNA | Putative Target gene | Biological Function | Tissue/cell type | Ref |
|---|---|---|---|---|
| miR-33 | ABCA1 | Cholesterol efflux, HDL biogenesis | Human hepatoma cell lines (HepG2, Huh7, Hep3B), mouse liver, mouse hepatic cell line (Hepa), J774, human endothelial cell lline (EAhy926), Primary mouse and human macrophages, Hepa, THP-1, Hep3B | [67] |
| [68] | ||||
| [69] | ||||
| ABCG1 | Cholesterol efflux | |||
| NPC1 | Intracellular cholesterol transport | |||
| miR-122 | Aldoa | Primary mouse hepatocytes | [60] | |
| Gysl | [61] | |||
| Ccngl | ||||
| P4hal | ||||
| Ndrg3 | ||||
| Tmed3 | ||||
| Hfe2 | ||||
| Slc35a4 | ||||
| miR-370 | CPT1a | Fatty acid oxidation | Human hepatoma cell line (HepG2) | [66] |