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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Exp Hematol. 2010 Sep 24;38(12):1167–1177. doi: 10.1016/j.exphem.2010.08.008

Figure 4.

Figure 4

Figure 4

Figure 4

Figure 4

Tonic Syk signaling is essential for CLL cell survival. A, R-CLL B-cells demonstrate constitutive phosphorylation of Syk. pSyk Y352 and total Syk were measured with BD CBA. B, ZAP-70 phosphorylation is similar between the CLL subsets. pZAP-70Y319 and total ZAP-70 were measured with BD CBA. C and D, Inhibition of Syk enhances DPP2 inhibition-induced apoptosis in CLL. PBMCs were incubated with 2 µM R406, AX8819 or both and assayed by flow cytometry. Representative data of three independent experiments are shown. The whiskers show standard deviation.