Skip to main content
. Author manuscript; available in PMC: 2011 Dec 29.
Published in final edited form as: Neuroscience. 2010 Oct 8;171(4):1357–1366. doi: 10.1016/j.neuroscience.2010.10.010

Figure 3.

Figure 3

LGE portions of VM-LGE co-transplants at 3 months postgrafting (a–c) in grafts derived from Gdnf +/+ (a), Gdnf +/− (b), and Gdnf −/−(c) tissues demonstrating TH (red) and DARPP-32 (green) –immunoreactivities. The distribution of TH-positive nerve fibers was patchy and dense and overlapped with areas dense with DARPP-32-positive neurons in Gdnf +/+ transplants (a), while these DARPP-32-positive areas mismatched somewhat with TH in grafts from Gdnf +/− (b). In transplants from Gdnf −/−, TH-positive nerve fibers never formed a dense patchy distribtion, and the expression of DARPP-32 was poor (c). In E19 Gdnf −/−fetal striatum, TH-positive nerve fibers did form a patchy distribution, which overlapped well with the presence of DARPP-32-positive neurons (d–f). Arrows delineate graft-host interface. Scale bar: a, c = 200 µm, b, d, e, f = 100 µm.