Table 2.
List of second-line anti-tuberculosis drugs
| Drug | Brand name (company) | Dose (mg) | Solubility (mg/ml) | BCS class | |
|---|---|---|---|---|---|
| Second line drugs | Ethionamide | Trecator® (Wyeth); Nisotin®; Trescatyl® (M&B); Aetina®; Ethimide®; lridocin® (Bayer). | 500 | 0.1 | II |
| Clarithromycin | Biaxin® (Abbott); Ciathromycin® (Taisho); Klaricid® (Abbott); Naxy® (Sanofi Winthrop); Veciam® (Zambon). | 500 | 0.00033 | II | |
| p-Aminosalicylic acid | PASER® (Jacobus); Rezipas® (Bristol- Myers Squibb). | 500 | 1.7 | Na | |
| Cycloserine | Closina®; Farmiserina® (Farmitalia); Micoserina®; Oxamycin® (Merck & Co.). | 500 | 100 | IV/II | |
| Amikacin | Sulfate-Amiglyde-V® (Fort Dodge); Amiklin®, BB-K8®, Biklin® (Bristol-Myers Squibb); Lukadin® (San Carlo); Mikavir® (Salus); Novamin® (Bristol-Myers Squibb). | 1000 | Na | III | |
| Kanamycin A | Kantrex® (Bristol-Myers Squibb). | 1000 | Na | N/A (i.v. or i.m.) | |
| Capreomycin | Capastat® (Dista), Capastat sulphate® (Eli Lilly). | 1000 | Soluble in water | N/A (i.v. or i.m) | |
| Levofloxacin | Cravit® (Daiichi); Levaquin® (Ortho-McNeil); Tavanic® (Aventis); Quixin® (Santen). | 500 | Sparingly soluble in water | N/A (i.v. or i.m) | |
| Linezolid | Zyvox®, Zyvoxid® (Pfizer). | 400 | Soluble in water up to 3 mg/ml | Na |
N/A: not applicable (administered by i.m. injection), Na: not available.