Table 1.
Env sequence characteristics of amino acid length and potential N-linked glycosylation sites for slow progressors and progressors#
| Patient | V1V2 | C2V3 | C3V4 | C4V5 | gp41 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| mean length (range) | mean PNGs (range) |
mean length (range) |
mean PNGs (range) |
mean length (range) | mean PNGs (range) | mean length (range) | mean PNGs (range) | mean length (range) | mean PNGs (range) | |
| Slow progressors | ||||||||||
| SK035 entry | 69 (62-72) | 6 (3-7) | 133 | 8 | 80 (75-81) | 7 (5-8) | 53 (52-56) | 3 (3-4) | 252 | 5 (3-5) |
| SK035 exit | 69 (59-70) | 6 (4-8) | 133 | 8 | 82 (80-88) | 7 (6-8) | 53 (52-58) | 3 (2-4) | 250(243-252) | 5 (4-5) |
| SK036 entry | 64 (61-73) | 5 (4-6) | 133 | 6 (7-8) | 84 (82-84) | 8 (8-9) | 52 | 3 (2-3) | 243(243) | 4 (3-5) |
| SK036 exit | 66 (59-73) | 4 (3-6) | 133 | 8 (7-8) | 84 | 8 (7-9) | 52 | 3 (2-3) | 243(243) | 5 (4-5) |
| SK169 entry | 75 (71-80) | 6 (5-7) | 133(132-133) | 6 (6-8) | 85 (84-88) | 7 (6-8) | 54 (52-55) | 3 (2-4) | 245(241-245) | 3 (3-4) |
| SK169 exit | 76 (71-77) | 7 (6-7) | 133 | 6 (6-8) | 86 (84-95) | 7 (4-10) | 54 (51-55) | 3 (2-4) | 245(245) | 3 (3-4) |
| SK312 entry | 66 (60-69) | 5(3-5) | 133 | 6 | 90 (85-97) | 9 (5-11) | 51 (50-54) | 3 (2-4) | 239(233-252) | 3 |
| SK312 exit | 67 (67-69) | 5 | 133 | 6 | 90 (84-97) | 8 (4-10) | 51 (50-55) | 3 (1-4) | 239(236-252) | 3 |
| Mean (range) over time | 69 (64-75) | 6 (4-7) | 133 | 7 (6-8) | 85 (81-90) | 8 (7-9) | 53 (51-54) | 3 | 245(239-252) | 4 (3-5) |
| Progressors | ||||||||||
| SK010 entry | 65 | 6 | 133 | 8 | 79 (77-82) | 8 (7-9) | 52 (52-53) | 3 | 252 | 3 |
| SK010 exit | 65 (65-66) | 6 | 133 | 8 | 78 (75-79) | 7 (5-8) | 52 (50-54) | 3 | 252 | 3 |
| SK200 entry | 66 (64-78) | 6 (6-7) | 133 | 8 | 76 (75-76) | 6 (6-7) | 52 | 2 (2-3) | 252 | 3 (2-3) |
| SK200 exit | 73 (71-73) | 6 (6-8) | 133 | 8 | 76 (75-76) | 7 | 52 | 3 | 252 | 3 (2-3) |
| SK221 entry | 72 (55-74) | 7 (3-8) | 133 | 9 | 77 (73-82) | 7 (7-8) | 51 | 3 (3-4) | 252 | 2 |
| SK221 exit | 71 (63-76) | 5 (4-5) | 133 | 9 | 85 (74-90) | 8 (6-9) | 51 | 3 (3-4) | 246(245-252) | 2 |
| SK233 entry | 58 | 4 | 133 | 8 | 84 (84) | 9 (8-9) | 52 (50-51) | 3 | 245 | 3 (3-4) |
| SK233 exit | 59 (59-63) | 5 (5-6) | 133 | 8 (7-8) | 84 (84) | 9 (8-9) | 53 (52-53) | 3 (2-4) | 245 | 3 (3-4) |
| Mean (range) over time | 66 (59-72) | 6 (4-7) | 133 | 8 (8-9) | 82 (76-88) | 8 (7-9) | 52 (51-53) | 3 (2-4) | 250(245-252) | 3 (2-3) |
| p Value | p = 0.32 | p = 0.78 | NS | *p = 0.009 | p = 0.02 | p = 0.96 | p = 0.29 | p = 0.15 | p = 0.02 | p = 0.02 |
p value was calculated using the two-tailed Mann-Whitney non-parametric test overall between the slow progressors and progressors.
Where only the mean is reflected it is because it is equivalent to the range.
* represents the p value that remained significant after Bonferroni adjustment for multiple comparisons (p < 0.01), NS represents a non-significant p value. Potential N-linked glycosylation = PNGs.
# Data for V1-V4 length is as follows: slow progressors had a mean of 286 amino acids (range 282-294) versus progressors' 281 amino acids (range 276-292; p = 0.009).
# Data for V1-V4 PNGs is as follows: slow progressors had a mean of 20 PNGS (range 19-21) versus a mean of 22 PNGs (range 20-23) in progressors (p = 0.02).