Table 3.
Comparison of measured and estimated parameters of parasite clearance
| A. PCT (hr): | |||||
|---|---|---|---|---|---|
| Patient (ID) | Drug |
Micr. observed |
qPCR* observed |
Micr. LL |
qPCR LL |
| 1 (OX007) | QN | 120 | - | 122 | 134 |
| 2 (OX005) | QN | 96 | - | 87 | 89 |
| 3 (OX006) | AS | 120 | - | 121 | 183 |
| 4 | QN; AP | - | - | 220 | 199 |
| B. PRR48 h (ratio, no units): | |||||
| Patient (ID) | Drug |
Micr. observed |
qPCR * observed |
Micr. LL |
qPCR LL |
| 1 (OX007) | QN | 80 | 30 | 100 | 50 |
| 2 (OX005) | QN | 100 000 | 100 000 | 25 000 | 25 000 |
| 3 (OX006) | AS | 50 | 14 | 100 | 14 |
| 4 | QN; AP | 10 | 7 | 10 | 10 |
| C. PCT95 (hr): | |||||
|
Patient (ID) Drug |
Drug |
Micr. observed |
qPCR * observed |
Micr. LL |
qPCR LL |
| 1 (OX007) | QN | 49 | 44 | 33 | 38 |
| 2 (OX005) | QN | 16 | 16 | 15 | 15 |
| 3 (OX006) | AS | 45 | 49 | 39 | 56 |
| 4 | QN; AP | 56 | 55 | 60 | 54 |
PCT Parasite Clearance Time
PRR48h Parasite Reduction Rate - ratio between admission count and 48 hours later
PCT95 (hr) the time required to clear 95% of parasites
LL log linear model for best fit
* All samples reported negative by microscopy were positive by RT-PCR and hence PCT was not directly observed by RT-PCR