Table 4.
Incidence of fibrosis in 3186 patients treated by breast-conserving surgery and radiation with or without systemic therapy.
| Crude | Actuarial | Actuarial | |||
|---|---|---|---|---|---|
| Characteristic | # | # (%) | 5 years | 10 years | p value |
| All patients | 3186 | 273 (8.6) | 11 | 17 | |
| Cup Size | <0.0001 | ||||
| A | 160 | 13 (8.1) | 9 | 15 | |
| B | 910 | 65 (7.1) | 10 | 13 | |
| C | 818 | 77 (9.4) | 13 | 21 | |
| D/E | 510 | 63 (12.4) | 19 | 34 | |
| Unknown | 788 | 55 (7.0) | 7 | 10 | |
| Boost Method | 0.7 | ||||
| Electron | 3087 | 263 (8.5) | 11 | 16 | |
| Photon | 99 | 10 (10.1) | 11 | 19 | |
| Boost Dose | 0.08 | ||||
| ≤ 10 Gy | 298 | 23 (7.7) | 8 | 15 | |
| 11 – 16 Gy | 1871 | 149 (8.0) | 10 | 15 | |
| > 16 Gy | 1017 | 104 (10.2) | 13 | 20 | |
| Boost Size | <0.0001 | ||||
| 4 – 6 cm | 1009 | 83 (8.2) | 11 | 16 | |
| 7 – 8 cm | 1269 | 125 (9.9) | 15 | 25 | |
| > 8 cm | 320 | 34 (10.6) | 20 | 29 | |
| Unknown | 588 | 31 (5.3) | 1 | 2 | |
| Boost Energy | <0.0001 | ||||
| 6 – 10 MeV | 943 | 53 (5.6) | 7 | 11 | |
| 12 – 16 MeV | 1631 | 152 (9.3) | 12 | 17 | |
| 18 – 21 MeV | 526 | 59 (11.2) | 16 | 32 | |
| Whole-breast Method | <0.0001 | ||||
| IMRT | 552 | 43 (7.8) | 20 | -- | |
| Conventional | 2634 | 230 (8.7) | 10 | 15 | |
| Location | 0.7 | ||||
| Inner | 656 | 63 (9.6) | 10 | 16 | |
| Outer | 1768 | 145 (8.2) | 13 | 17 | |
| Central | 626 | 52 (8.3) | 10 | 17 | |
| Subareolar | 136 | 13 (9.6) | 11 | 13 | |
| Adjuvant Systemic Therapy | <0.0001* | ||||
| Chemotherapy | 266 | 40 (15.0) | 9 | 17 | |
| Tamoxifen | 802 | 98 (12.2) | 15 | 28 | |
| Both | 363 | 41 (11.3) | 14 | 20 | |
| None | 761 | 94 (12.4) | 8 | 10 |