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. Author manuscript; available in PMC: 2010 Nov 26.
Published in final edited form as: Circ Res. 2010 Oct 7;107(11):1364–1373. doi: 10.1161/CIRCRESAHA.110.227454

Figure 8. Ischemia reperfusion injury is enhanced in apoE-/- mice with inflammatory atherosclerosis, and attenuated by Enalapril and splenectomy.

Figure 8

A: Fluorescence reflectance images display the area at risk, which is void of microspheres injected during ischemia. Lower panel shows TTC staining of the same myocardial short axis slice.

B: Quantification of ischemia reperfusion injury as a percentage of the area at risk. Mean ± SEM; * p < 0.05 versus all other groups.

C: Representative flow cytometry dot plots of heart tissue from apoE-/- mice 1 day after ischemia. The gate shows CD11b positive lineage negative monocytes and macrophages.

D: Quantification of CD11b positive lineage negative monocytes/macrophages. * p < 0.05 versus all other groups.

E: Flow cytometric quantification of splenic monocytes 24 hours after ischemia in apoE-/- mice with and without Enalapril treatment (ACEi). Mean ± SEM; * p < 0.05.