Table 1.
Table shows the baseline characteristics of the patients in the VISTA classified by the presence of diabetes, presence of prior stroke, and presence of prior stroke and concomitant diabetes
| Group of diabetic patients |
Group of prior stroke patients |
Group of concomitant diabetes and prior stroke* |
||||
|---|---|---|---|---|---|---|
| Alteplase | No alteplase | Alteplase | No alteplase | Alteplase | No alteplase | |
| Age** | ||||||
| Mean | 69.5 (10.9), n = 342 | 70.3 (10.8), n = 992 | 70.6 (12.6), n = 319 | 73.2 (10.9), n = 1,579 | 71.2 (10), n = 86 | 71.8 (9.8), n = 405 |
| Median | 71 (33–98) | 72 (30–96) | 73 (21–98) | 75 (30–101) | 73 (46–98) | 73 (37–90) |
| P = 0.2 | P = 0.0002 | P = 0.6 | ||||
| Sex (male) | 198/342 (57.9%) | 532/992 (53.6%) | 180/319 (56.4%) | 822/1,579 (52.1%) | 54/86 (62.8%) | 212/405 (52.3%) |
| P = 0.17 | P = 0.2 | P = 0.07 | ||||
| Baseline NIHSS | 13 (5–30) | 13 (2–29) | 13 (3–30) | 12 (2–37) | 13.5 (5–30) | 12 (2–29) |
| P = 0.01 | P = 0.02 | P = 0.03 | ||||
| Atrial fibrillation | 82/342 (24%) | 256/992 (34.5%) | 82/312 (26.3%) | 501/1,494 (33.5%) | 18/86 (20.9%) | 105/405 (25.9%) |
| P < 0.05 | P = 0.009 | P = 0.3 | ||||
| Hypertension | 278/342 (81.3%) | 795/992 (80.1%) | 240/312 (76.9%) | 1,162/1,494 (77.8%) | 76/86 (88.4%) | 332/405 (82%) |
| P = 0.6 | P = 0.7 | P = 0.2 | ||||
| Prior use of antiplatelets | 120/241 (49.8%) | 145/348 (41.7%) | 119/186 (64%) | 168/349 (48.1%) | 37/51 (72.5%) | 62/105 (59.0%) |
| P = 0.053 | P = 0.001 | P = 0.09% | ||||
| Prior anticoagulants | 17/241 (7.1%) | 44/348 (12.6%) | 18/186 (9.7%) | 77/349 (22.1%) | 5/51 (9.8%) | 20/105 (19.0%) |
| P = 0.03 | P < 0.05 | P = 0.1 | ||||
| Use of antithrombotics | 129/241 (53.5%) | 173/348 (49.7%) | 128/186 (68.8%) | 225/349 (64.5%) | 38/51 (74.5%) | 72/105 (68.6%) |
| P = 0.04 | P = 0.3 | P = 0.4 | ||||
| Myocardial infarction | 94/342 (27.5%) | 202/992 (20.4%) | 79/312 (25.3%) | 299/1,494 (20%) | 26/86 (30.2%) | 87/405 (21.5%) |
| P = 0.009 | P = 0.047 | P = 0.1 | ||||
| Congestive cardiac failure | 46/272 (16.9%) | 50/374 (13.4%) | 40/197 (20.3%) | 45/359 (12.5%) | 11/53 (20.7%) | 13/110 (11.8%) |
| P = 0.2 | P = 0.02 | P = 0.2 | ||||
P value refers to the comparison between the treated and nontreated group corresponding to each variable.
*The group comprising diabetes and prior stroke was compared specifically against those patients who had neither of the two factors.
**Age is described with mean and SD (above) and median (range) (below).