Table 1.
Baseline clinical and laboratory characteristics of 283 type 2 diabetic patients divided according to tertiles of OPG (<1,691; 1,691–2,219; and >2,219 pg/ml)
| 1st tertile | 2nd tertile | 3rd tertile | P | |
|---|---|---|---|---|
| n | 94 | 95 | 94 | |
| Male (%) | 57 | 63 | 62 | 0.71 |
| Age (years) | 50 ± 10 | 54 ± 8 | 59 ± 6 | <0.001 |
| Duration of diabetes (years) | 5 (1–39) | 7 (1–31) | 8 (1–34) | 0.15 |
| BMI (kg/m2) | 28.6 ± 5.4 | 28.7 ± 5.0 | 28.3 ± 4.7 | 0.86 |
| A1C (%) | 7.7 ± 1.7 | 8.0 ± 1.8 | 8.4 ± 2.0 | 0.052 |
| Retinopathy (%) | 28 | 31 | 43 | 0.038 |
| Nephropathy (normo-/micro-/macroalbuminuria) (%) | 73/15/12 | 57/30/13 | 48/33/19 | 0.007 |
| UAER (mg/24 h) | 10 (1–5,108) | 23 (1–3,969) | 38 (1–8,019) | <0.001 |
| eGFR (ml/min/1.73 m2) | 99 (58–159) | 94 (52–239) | 81 (12–131) | <0.001 |
| Smoking (%) | 35 | 32 | 32 | 0.77 |
| Systolic blood pressure (mmHg) | 145 ± 22 | 147 ± 19 | 160 ± 24 | <0.001 |
| Diastolic blood pressure (mmHg) | 85 ± 11 | 84 ± 11 | 87 ± 13 | 0.37 |
| Total cholesterol (mmol/l) | 5.9 ± 1.2 | 6.4 ± 1.6 | 6.7 ± 2.0 | 0.006 |
| NT-proBNP (ng/ml) | 52 (5–544) | 53 (5–3,768) | 93 (12–3,023) | <0.001 |
| Known ischemic heart disease (%) | 12 | 18 | 31 | 0.004 |
| OPG (pg/ml) | 1,428 (439–1,691) | 1,962 (1,695–2,218) | 2,743 (2,235–5,400) | <0.001 |
Data are given as (%), means ± SD, or medians (range).