Table 3.
Multivariable-adjusted associations of total magnesium intake (quintiles) with inflammatory markers and HOMA-IR
| Quintiles of total magnesium intake |
Ptrend | |||||
|---|---|---|---|---|---|---|
| 1 (lowest) | 2 | 3 | 4 | 5 (highest) | ||
| hs-CRP (n = 4,157) | ||||||
| Median (mg/l) | 1.60 | 1.37 | 1.27 | 1.00 | 0.86 | |
| Model 1 | 0 | −0.071 (−0.153 to 0.012) | −0.008 (−0.093 to 0.077) | −0.151 (−0.245 to −0.057) | −0.270 (−0.368 to −0.172) | <0.01 |
| Model 2 | 0 | −0.069 (−0.149 to 0.012) | 0.012 (−0.071 to 0.095) | −0.095 (−0.186 to −0.004) | −0.190 (−0.286 to −0.094) | <0.01 |
| Model 3 | 0 | −0.058 (−0.140 to 0.024) | 0.028 (−0.057 to 0.114) | −0.071 (−0.166 to 0.024) | −0.160 (−0.262 to −0.058) | <0.01 |
| IL-6 (n = 3,254) | ||||||
| Median (mg/l) | 2.26 | 1.96 | 1.66 | 1.54 | 1.39 | |
| Model 1 | 0 | −0.097 (−0.185 to −0.009) | −0.154 (−0.245 to −0.062) | −0.201 (−0.296 to −0.105) | −0.284 (−0.383 to −0.186) | <0.01 |
| Model 2 | 0 | −0.088 (−0.174 to −0.002) | −0.134 (−0.223 to −0.044) | −0.141 (−0.236 to −0.045) | −0.217 (−0.317 to −0.118) | <0.01 |
| Model 3 | 0 | −0.082 (−0.169 to 0.005) | −0.121 (−0.214 to −0.029) | −0.125 (−0.225 to −0.025) | −0.200 (−0.306 to −0.094) | <0.01 |
| Fibrinogen (n = 4,325) | ||||||
| Median (mg/l) | 314 | 319 | 319 | 316 | 306 | |
| Model 1 | 0 | −0.010 (−0.023 to 0.004) | −0.003 (−0.018 to 0.011) | −0.018 (−0.033 to −0.002) | −0.038 (−0.055 to −0.021) | <0.01 |
| Model 2 | 0 | −0.007 (−0.020 to 0.007) | 0.005 (−0.009 to 0.019) | −0.003 (−0.018 to 0.012) | −0.015 (−0.032 to 0.002) | 0.08 |
| Model 3 | 0 | −0.007 (−0.021 to 0.006) | 0.003 (−0.012 to 0.017) | −0.006 (−0.022 to 0.010) | −0.020 (−0.038 to −0.002) | 0.03 |
| HOMA-IR (n = 4,239) | ||||||
| Median (mg/l) | 2.66 | 2.63 | 2.50 | 2.36 | 2.11 | |
| Model 1 | 0 | −0.046 (−0.081 to −0.012) | −0.040 (−0.077 to −0.003) | −0.085 (−0.123 to −0.047) | −0.153 (−0.195 to −0.112) | <0.01 |
| Model 2 | 0 | −0.045 (−0.077 to −0.013) | −0.036 (−0.070 to −0.002) | −0.068 (−0.103 to −0.033) | −0.122 (−0.160 to −0.084) | <0.01 |
| Model 3 | 0 | −0.046 (−0.078 to −0.013) | −0.036 (−0.071 to −0.000) | −0.065 (−0.102 to −0.029) | −0.117 (−0.157 to −0.077) | <0.01 |
Data are β coefficients (95% CIs) unless otherwise indicated. A logarithmic transformation was used to improve the normality of distribution for dependent variables. Generalized estimating equations were used for repeated measurements of hs-CRP, fibrinogen, and HOMA-IR, and a general linear regression model was used for IL-6. The median magnesium level in each quintile was created for the trend tests. The adjusted covariates in the models were the same as those listed in Table 2.