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Fibrinogen binding to CHO cells expressing αIIbβ3 containing β3 stalk mutations. Alexa Fluor 488 fibrinogen binding to αIIbβ3 was measured by flow cytometry in the absence (constitutive binding) or presence (stimulated binding) of 5 mm DTT. Fibrinogen-binding measurements were used to calculate a fibrinogen-binding index relative to WT for each mutation, as described under “Experimental Procedures.” Data shown are the mean ± S.E. (error bars) of three to six measurements.
