Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Predicted consequences of β3 stalk mutations
βTD, β-tail domain.
| β3 mutant | Location | Predicted ΔΔG | Classification |
|---|---|---|---|
| kcal/mol | |||
| Y594A | EGF-4 | 0.60 | Destabilizing |
| T603A | βTD | 2.89 | Destabilizing |
| K658A | βTD | 0.63 | Destabilizing |
| V664A | βTD | 0.34 | Destabilizing |
| V664K | βTD | Destabilizing | |
| D552A | EGF-3 | 0 | Neutral |
| H626A | βTD | 0 | Neutral |
| V664L | βTD | −0.7 | Stabilizing |
| T656W | βTD | −1.5 | Stabilizing |
