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. 2010 Oct 6;285(49):38666–38673. doi: 10.1074/jbc.M110.155036

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FIGURE 4. — Scavenging STIM1 with Orai1(R91W) inhibits the TRPC3 but not TRPC3(D697K,D698K) current. HEK cells were transfected with M3 receptors; wild-type TRPC3 (A and B) or TRPC3(D697K,D698K) (TRPC3(DD/KK), C3(DD/KK); C and D); and empty vector (thin black traces), Orai1(R91W) (thick black traces), or Orai1(R91W) + STIM1 (gray traces). A and C, examples of the time dependence of the current; B and D, I/V at peak current; E, mean ± S.E. of current density at −80 mV in pA/pF from the indicated number of experiments. *, p < 0.01 of TRPC3 + Orai1(R91W) (O1(R91W)) relative to wild-type TRPC3. All others were not different from wild-type TRPC3.