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. 2010 Oct 6;285(49):38684–38691. doi: 10.1074/jbc.M110.155192

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — Altered O-GlcNAc cycling modulates DILP expression. A, gene expression levels of dilp2, dilp3, and dilp5 in the third instar larvae were evaluated by quantitative real time PCR. Control experiments were carried out with Drosophila Actin42. Data are expressed as the means ± S.E. (n = 10). Dilp levels were decreased in dILP2GAL4/+;UAS-dOGTRNAi/+ (OGT-RNAi) but increased in dILP2GAL4/+;UAS-dOGARNAi/+ (OGA-RNAi) compared with control. *, p < 0.05; **, p < 0.001 versus the control. B, third instar larval brain was stained with rabbit anti-Drosophila insulin (DILP2) antibody. DILP2 staining in IPCs was decreased in OGT-RNAi but increased in OGA-RNAi.