Figure 2.

Myc regulates glycolysis and glutaminolysis. Myc upregulation leads to increased energy production through glycolysis and increased growth through glutaminolysis. The growth-promoting activity of the mTORC1 complex is controlled by flux through growth factor signaling pathways and intracellular bioenergetic charge via the AMP-dependent protein kinase AMPK. We propose that increased leucine uptake in Myc-overexpressing cells could lead to mTORC1 activation. Glc = glucose; Gln = glutamine; Glu = glutamate; Leu = leucine; Ac-CoA = acetyl Co-A; GLS1 = glutaminase 1; LDH-A = lactate dehydrogenase. *Myc-activated target. **Myc-repressed target.