Table 1.
Baseline characteristics of case and control participants from the Women's Health Study (n=718) and Physicians' Health Study II (n=340)
| WOMEN | MEN | |||||
|---|---|---|---|---|---|---|
| Cases | Controls | p-value* | Cases | Controls | p-value* | |
| n | 359 | 359 | 170 | 170 | ||
| Age (mean ± SD) | 60.3 ±6.1 | 60.3 ±6.1 | (matched) | 63.7 ±7.6 | 63.7 ±7.6 | (matched) |
| Race, White | 332 (93.5%) | 332 (93.5%) | (matched) | 145 (85.3%) | 145 (85.3%) | (matched) |
| BMI (mean ± SD) | 30.9 ±6.1 | 26.0 ±5.0 | <0.0001 | 28.9 ±3.9 | 25.5 ±3.4 | <0.0001 |
| Current multivitamin use | 82 (22.9%) | 88 (25.2%) | 0.47 | 47 (27.7%) | 46(27.1%) | 0.90 |
| Current smoker | 52 (14.5%) | 49 (13.7%) | 0.74 | 11 (6.5%) | 2 (1.2%) | 0.01 |
| Exercise, ≥4 times/week | 32 (8.9%) | 41 (11.4%) | 0.27 | 16 (9.4%) | 21 (12.4%) | 0.38 |
| Family history of diabetes | 174 (48.5%) | 86 (24.0%) | <0.001 | 56 (32.9%) | 29(17.1%) | 0.0007 |
| Alcohol consumption, ≤1 drink/day hs-CRP (mg/L) | 18 (5.0%) | 41 (11.4%) | 0.002 | 49 (28.8%) | 46(27.1%) | 0.72 |
| <0.0001† | - | |||||
| Median | 4.0 | 1.6 | - | - | ||
| Interquartile range | 2.3-7.0 | 0.7-3.6 | - | - | ||
| TNF-RII (pg/mL) | 0.002† | 0.24† | ||||
| Median | 2825 | 2645 | 2298 | 2215 | ||
| Interquartile range | 2334-3331 | 2275-3125 | 1985-2647 | 1946-2562 | ||
| Resistin (ng/mL) | <0.0001† | 0.09† | ||||
| Median | 11.7 | 10.4 | 10.6 | 9.1 | ||
| Interquartile range | 8.7-17.6 | 7.5-13.9 | 6.6-16.0 | 6.4-12.8 | ||
| rs1862513 | 0.99 | 1.00 | ||||
| GG | 175 (49.3%) | 174 (49.3%) | 71(43.0%) | 71(43.0%) | ||
| CG | 149 (42.0%) | 147 (41.6%) | 76(46.1%) | 76(46.1%) | ||
| CC | 31(8.7%) | 32 (9.1%) | 18 (10.9%) | 18 (10.9%) | ||
| Minor allele frequency | 30% | 30% | 34% | 34% | ||
| rs34861192 | 0.10 | 0.12 | ||||
| GG | 348 (98.3%) | 338 (95.5%) | 162 (96.4%) | 151 (91.0%) | ||
| GA | 5 (1.4%) | 13 (3.7%) | 5 (3.0%) | 12(7.2%) | ||
| AA | 1 (0.3%) | 3 (0.9%) | 1 (0.6%) | 3 (1.8%) | ||
| Minor allele frequency | 1% | 3% | 2% | 5% |
*
Chi-square test for comparing cases and controls in categorical variables. Wilcoxon signed rank test for comparing cases and controls in continuous variables.
†
Wilcoxon signed rank test comparing log-transformed biomarker levels by case-control status.