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. 2010 Dec;24(12):4648–4659. doi: 10.1096/fj.10-162230

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/us/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Mechanisms of ANGPTL4-mediated resorption. A, B) Effect of 24 h exposure to ANGPTL4 (100 ng/ml, shaded bars) on osteoclast viability (A) and relative resorption (B) in comparison with the untreated control (open bars) after treatment with HIF-1α (H1) or scrambled control (scr) siRNA. C) Effect of ANGPTL4 siRNA (A1 and A2) on hypoxic induction of ANGPTL4 mRNA (open bars) and resorption (shaded bars) in comparison with scrambled hypoxic control siRNA. D) Effect of ANGPTL4 (100 ng/ml) on osteoclast viability during 24 h exposure to OPG (500 ng/ml). E) Effect of ANGPTL4 (100 ng/ml) on resorption during 24 h exposure to OPG (500 ng/ml). *P < 0.05; **P < 0.01; ***P < 0.001.