Table 1.
HIF target genes induced by hypoxia in the osteoclast microarray
| Gene symbol | Gene name | Fold induction | P value | Accession no. |
|---|---|---|---|---|
| ANGPTL4 | Angiopoietin-like 4 | 14.3 | 0.0004 | NM_139314.1 |
| PLOD2 | Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 7.4 | 0.0003 | NM_182943.2 |
| STC2 | Stanniocalcin 2 | 7 | 0.00001 | NM_003714.2 |
| CA12 | Carbonic anhydrase XII | 6.6 | 0.002 | NM_001218.3 |
| MT3 | Metallothionein 3 | 6.2 | 0.00003 | NM_005954.2 |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | 5.1 | 0.02 | NM_003467.2 |
| NM_001008540.1 | ||||
| DDIT4 | DNA-damage-inducible transcript 4 | 4.5 | 0.002 | NM_019058.2 |
| ANG | Angiogenin, ribonuclease, RNase A family, 5 | 3.6 | 0.003 | NM_001145.2 |
| BNIP3 L | BCL2/adenovirus E1B 19-kDa interacting protein 3-like (NIX) | 3.2 | 0.0002 | NM_004331.2 |
| PFKFB4 | 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 3.2 | 0.0003 | NM_004567.2 |
| ERO1L | ERO1-like (Streptomyces cerevisiae) | 3 | 0.00002 | NM_014584.1 |
| BNIP3 | BCL2/adenovirus E1B 19-kDa interacting protein 3 | 2.7 | 0.0002 | NM_004052.2 |
| VEGF | Vascular endothelial growth factor A | 2.7 | 0.003 | NM_001025366.1 |
| NM_003376.4 | ||||
| MXI1 | MAX interactor 1 | 2 | 0.0001 | NM_001008541.1 |
| PGK1 | Phosphoglycerate kinase 1 | 2 | 0.0002 | NM_000291.2 |
| P4HA2 | Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), α polypeptide II | 2 | 0.006 | NM_001017974.1 |