Table 2.
Top hypoxia-inducible genes in the osteoclast microarray; not HIF target genes
| Gene symbol | Gene name | Fold change | P value | Accession no. |
|---|---|---|---|---|
| ZNF395 | Zinc finger protein 395 | 7.2 | 0.0009 | NM_018660.2 |
| PNCK | Pregnancy upregulated nonubiquitously expressed CaM kinase | 6.2 | 0.00005 | NM_198452.1 |
| TMEM45A | Transmembrane protein 45A | 5.6 | 0.001 | NM_018004.1 |
| VLDLR | Very low density lipoprotein receptor | 5.3 | 0.00001 | NM_001018056.1 |
| SPAG4 | Sperm associated antigen 4 | 5 | 0.00001 | NM_0063116.1 |
| PPP1R3C | Protein phosphatase 1, regulatory (inhibitor) subunit 3C | 5 | 0.0002 | NM_005398.3 |
| FGF11 | Fibroblast growth factor 11 | 4.7 | 0.00001 | NM_004112.2 |
| CCL20 | Chemokine (C-C motif) ligand 20 (MIP3A) | 4.5 | 0.00063 | NM_004591.1 |
| NM_199165.1 | ||||
| ADSSL1 | Adenylosuccinate synthase like 1 | 4.5 | 0.006 | NM_152328.3 |
| ENO2 | Enolase 2 | 4.4 | 0.0005 | NM_001975.2 |
| SULF2 | Sulfatase 2 | 4.2 | 0.001 | NM_018837.2 |
| PSAT1 | Phosphoserine aminotransferase 1 | 4.1 | 0.00002 | NM_021154.3 |
| PPFIA4 | Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein α 4 | 4 | 0.00003 | NM_015053.1 |
| CD300A | CD300a molecule | 4 | 0.0005 | NM_007261.2 |
| EEF1A2 | Eukaryotic translation elongation factor 1 α 2 | 3.8 | 0.00001 | NM_001958.2 |
| ADFP | Adipose differentiation-related protein | 3.8 | 0.02 | NM_001122.2 |
| PTGS2 | Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase, COX2) | 3.7 | 0.0001 | NM_000963.1 |
| RSNL2 | CAP-GLY domain containing linker protein family, member 4 | 3.6 | 0.0004 | NM_024692.3 |
| LOC652879 | Similar to phosphodiesterase 4D interacting protein isoform 2 | 3.6 | 0.0005 | XM_942594.1 |
| NM_194430.1, | ||||
| RNASE4 | Ribonuclease, RNase A family, 4 | 3.5 | 0.001 | NM_002937.3 |
| TMEM71 | Transmembrane protein 71 | 3.4 | 0.00001 | NM_144649.1 |
| DPYSL4 | Dihydropyrimidinase-like 4 | 3.4 | 0.0003 | NM_006426.1 |
| KISS1R | KISS1 receptor | 3.2 | 0.0005 | NM_032551.3 |
| BTG1 | B-cell translocation gene 1 | 3.2 | 0.0008 | NM_001731.1 |
| PDE2A | Phosphodiesterase 2A, cGMP-stimulated | 3 | 0.00001 | NM_002599.1 |
| TSC22D3 | TSC22 domain family, member 3 | 2.9 | 0.002 | NM_004089.3 |
| ACOT11 | Acyl-CoA thioesterase 11 | 2.7 | 0.00001 | NM_147161.2 |
| LOC653853 | Similar to hypothetical protein FLJ40722, transcript variant 2 | 2.7 | 0.0004 | XM_936029.1 |
| ADORA2B | Adenosine A2b receptor | 2.7 | 0.002 | NM_000676.2 |
| SORL1 | Sortilin-related receptor, L (DLR class) A repeats-containing | 2.6 | 0.001 | NM_003105.3 |
| C1orf165 | Chromosome 1 open reading frame 165 | 2.4 | 0.0003 | NM_024603.1 |
| ICAM5 | Intercellular adhesion molecule 5, telencephalin | 2.4 | 0.0005 | NM_003259.2 |
| LOC146439 | Hypothetical LOC146439 | 2.3 | 0.00002 | XM_940000.1 |
| LOC644782 | Similar to implantation-associated protein | 2.3 | 0.0001 | XM_927878.1 |
| NM_133280.1 | ||||
| FCAR | Fc fragment of IgA, receptor for | 2.3 | 0.002 | NM_133271.1 |
| ANKZF1 | Ankyrin repeat and zinc finger domain containing 1 | 2.2 | 0.0002 | NM_018089.1 |
| MGC17330 | Phosphoinositide-3-kinase interacting protein 1 | 2.2 | 0.0005 | NM_052880.3 |
| FER1L4 | Fer-1-like 4 (Caenorhabditis elegans) | 2.1 | 0.00001 | NR_001442.2 |
| CCL28 | Chemokine (C-C motif) ligand 28 (CCK1) | 2.1 | 0.0001 | NM_019846.3 |
| PPP1R3G | Protein phosphatase 1, regulatory (inhibitor) subunit 3G | 2.1 | 0.0004 | XM_371796.2 |
| FLJ40722 | Hypothetical protein FLJ40722, transcript variant 4 | 2 | 0.00005 | XM_945696.1 |
| LRRC6 | Leucine rich repeat containing 6 | 2 | 0.0001 | NM_012472.3 |
| NM_001018021.1 | ||||
| MUC1 | Mucin 1 | 2 | 0.0003 | NM_001044390.1 |