Calbindin marks the human cortical hem and choroid plexus anlage. (A) Human embryo at Carnegie stage 19 (6.5 GW), horizontal section. CH, cortical hem; ChP, choroid plexus; TE, Thalamic eminence; III, third ventricle. (B) The cortical hem at 9 GW, coronal section. At the moment of highest production of CR cells, the hem and choroid plexus are strongly ir for calbindin (compare with Fig. 5A). M, head mesenchyme; S, septum. (C) At 13 GW the cortical hem has disappeared, and its site is now occupied by the fimbria (F). Only the stalk of the choroid plexus is calbindin-ir. HC, hippocampus. Scales: (A) 500 μm, (B) 250 μm, (C) 300 μm.