Table 1.

Summary of reported cases of endometrial carcinoma treated with progesterone-IUD or LNG-IUS

Author year reference	No. of cases	Age years	Associated condition	Presenting symptom	Clinical staging/ initial histology	Treatment	Follow-up response
Montz et al., 2002 [19]	1–12				endometrioid carcinoma stage I, grade 1	Progestasert®	7 of 11 cases showed negative malignant endometrial cells at treatment month 6. 6 of 8 cases showed negative malignant endometrial cells at treatment month 12
Baha-mondes et al., 2003 [12]	1	31	morbid obesity	menorrhagia	endometrial carcinoma stage I, grade 1	LNG-IUS	7 months after insertion, pathological report of radical hysterectomy revealed grade 1 endometrioid carcinoma restricted to the endometrial mucosa
	2	62	morbid obesity	postmeno-pausal bleeding	endometrial carcinoma stage I, grade 1	LNG-IUS	6 months after insertion, pathological report of radical hysterectomy revealed grade 1 mixed endometrioid and mucinous well-differentiated adenocarcinoma with invasion of half of the myometrium
Gianno-poulos et al., 2004 [13]	1	78	Morbid obesity, hypertension, coronary artery disease	postmeno-pausal bleeding	endometrial adenocarcinoma background of atypical hyperplasia stage I, grade 1	LNG-IUS and MPA 400 mg/day	Predominantly pseudodecidualised stroma with small inactive glands at treatment month 5
Dhar et al., 2005 [11]	1	64	obesity, diabetes mellitus	postmeno-pausal bleeding	endometrial adenocarcinoma background of atypical hyperplasia/stage I, grade 1	LNG-IUS	Inactive endometrium at treatment month 6 and remission at treatment month 36
	2	73	obesity, diabetes mellitus, chronic lymphatic leukemia	postmeno-pausal bleeding	endometrial adenocarcinoma background of atypical hyperplasia/stage I, grade 1	LNG-IUS	Hysterectomy was performed (at treatment month 6 after insertion) due to persistence of bleeding, histopathological report still showed grade 1 endometrial adenocarcinoma
	3	80	obesity, diabetes mellitus, multiple cardiovascular accident	postmeno-pausal bleeding	endometrial adenocarcinoma stage I, grade 1	LNG-IUS	Intermittent symptom, died of pneumonia at month 24 after insertion
	4	73	obesity, diabetes mellitus, aortic stenosis, left brachial embolectomy	postmeno-pausal bleeding	endometrial adenocarcinoma stage I, grade 1	LNG-IUS	Persistent of diseases at treatment month 18, histopathological report still showed endometrioid adenocarcinoma