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. 2010 Aug 25;1(10):655–660. doi: 10.1021/cn100067e

Figure 4.

Figure 4

RP-HPLC and mass spectrometry (MS) analyses of peptide fragments formed from reaction of Aβ(1−42) peptides with the h20S proteasome: (A) RP-HPLC traces of Aβ(1−42) with (red) or without (blue) incubation with h20S proteasome; (B) summary of the amino acid sequence of the observed fragments of Aβ(1−42) and the proposed h20S proteasome cleavage sites as estimated by LC-MS analysis of each HPLC peak (for a list of masses, see Table S1 in the Supporting Information); (C) summary of the amino acid sequence of the observed fragments of Aβ(1−42) and the proposed h20S proteasome cleavage sites as estimated by TOF-MS/MS (for a list of masses, see Table S2 in the Supporting Information).