Table 1. Values for Kinetic Parameters of the Chymotrypsin-Like Activity of the Proteasome in the Presence of Different Concentrations of Oligomeric Aβ(1−42) Peptides.

Aβ conc (μM)	KM,obs (μM)	Ki (μM)	Vmax (× 10−2 μM/min)
0	5.9 ± 0.8a		3.1 ± 0.1
0.5	8.4 ± 1.3	1.2	3.1 ± 0.1
1	20 ± 4.2	0.4	3.5 ± 0.2
5	38 ± 9.1	0.9	3.7 ± 0.3

^aK_M,obs equals the apparent K_M of the LLVY-AMC substrate when no Aβ is present.