Table 2.
Single biomarker candidates from univariate analysis of CSF sample comparison of MMD and control groups
| P-value* | m/z | pH of binding/washing buffer | ROC AUC | Level in MMD |
|---|---|---|---|---|
| 1.60E-04 | 4746.76 | pH 9 | 0.9000 | up |
| 5.32E-04 | 4566.71 | pH 5 | 0.8583 | down |
| 6.14E-04 | 4473.46 a | pH 5 | 0.8750 | up |
| 1.08E-03 | 4157.65 | pH 9 | 0.8250 | up |
| 1.41E-03 | 4589.34 b | pH 9 | 0.8250 | up |
| 1.41E-03 | 50989.55 | pH 9 | 0.8417 | down |
| 1.41E-03 | 4588.73 b | pH 5 | 0.8250 | up |
| 3.09E-03 | 4588.87 b | pH 7 | 0.8000 | up |
| 3.09E-03 | 6941.48 d | pH 9 | 0.8083 | down |
| 3.51E-03 | 6942.96 d | pH 7 | 0.8167 | down |
| 7.24E-03 | 9656.51 | pH 5 | 0.8000 | up |
| 7.24E-03 | 13754.72 | pH 5 | 0.7750 | up |
| 8.12E-03 | 4809.94 c | pH 5 | 0.7667 | down |
| 9.11E-03 | 2406.55 | pH 5 | 0.7667 | down |
| 9.11E-03 | 13882.19 e | pH 9 | 0.7583 | down |
| 1.02E-02 | 9728.65 | pH 5 | 0.7750 | up |
| 1.14E-02 | 6228.21 | pH 5 | 0.7333 | down |
| 1.27E-02 | 13877.49 e | pH 7 | 0.7917 | down |
| 1.42E-02 | 21299.65 | pH 5 | 0.7583 | down |
| 1.58E-02 | 5781.11 | pH 5 | 0.7500 | up |
| 1.76E-02 | 14060.91 | pH 9 | 0.7417 | down |
| 1.76E-02 | 4695.40 | pH 5 | 0.7417 | down |
| 1.95E-02 | 6240.88 | pH 9 | 0.7500 | up |
| 2.16E-02 | 28095.59 | pH 9 | 0.7583 | down |
| 2.40E-02 | 4475.1 a | pH 7 | 0.7500 | up |
| 2.40E-02 | 7250.89 | pH 7 | 0.7250 | up |
| 2.40E-02 | 3516.49 | pH 9 | 0.7250 | up |
| 2.93E-02 | 6888.58 | pH 5 | 0.7250 | up |
| 3.23E-02 | 3681.83 | pH 9 | 0.7250 | up |
| 3.56E-02 | 1041.03 | pH 9 | 0.7000 | up |
| 3.91E-02 | 7146.84 | pH 5 | 0.7333 | down |
| 4.30E-02 | 4811.33 c | pH 9 | 0.7000 | up |
| 4.71E-02 | 1061.94 | pH 9 | 0.7250 | up |
| 4.71E-02 | 34344.75 | pH 5 | 0.7083 | down |
a-eValues with the same lower-case letter indicate clusters most likely derived from the same proteins. *P < 0.05, Mann-Whitney U test