Table 6.
Haplotype distribution in patients and controls and association with breast cancer risk
| Cases | Controls | |||||||
|---|---|---|---|---|---|---|---|---|
| Haplotype | N | F | N | F | OR | 95%CI | P χ2 | |
| AAGT | 284 | 0.47 | 248 | 0.47 | 1 | |||
| 1 | AAGC | 72 | 0.12 | 63 | 0.12 | 0.99 | 0.68-1.45 | 0.92 |
| GACC | 60 | 0.1 | 48 | 0.09 | 1.09 | 0.72-1.62 | 0.68 | |
| AACC | 54 | 0.09 | 42 | 0.08 | 1.12 | 0.72-1.73 | 0.65 | |
| GAGC | 6 | 0.01 | 0 | 0 | 0.03* | |||
| Total | 192 | 0.32 | 153 | 0.29 | 1.09 | 0.83-1.43 | 0.5 | |
| 2 | AGGT | 66 | 0.11 | 53 | 0.1 | 1.08 | 0.72-1.62 | 0.68 |
| AACT | 30 | 0.05 | 26 | 0.05 | 1.00 | 0.58-1.75 | 1 | |
| GACT | 24 | 0.04 | 26 | 0.05 | 0.80 | 0.45-1.44 | 0.46 | |
| AGCT | 0 | 0 | 5 | 0.01 | 0.02* | |||
| GAGT | 0 | 0 | 5 | 0.01 | 0.02* | |||
| Others | 8 | 0.01 | 12 | 0.02 | 0.58 | 0.23-1.44 | 0.23 | |
| Total | 128 | 0.21 | 127 | 0.24 | 0.88 | 0.65-1.18 | 0.4 | |
| Total | 604 | 1 | 528 | 1 | ||||
The haplotype combining the predominant alleles was used as a reference. Group 1 was formed by any haplotype containing the rs5275 C allele and group 2 included all the other haplotypes. The haplotypes with less than 1% frequency (Others) are not listed. The impact on breast cancer risk was calculated for the two groups, considering the Odds Ratio (OR) and the 95% Confidence Interval (95%CI) P: Pearson P-value; N: Number of haplotypes. F: Frequency of haplotypes. * Fisher Exact Probability Test (two-tailed). OR was not calculated because of N = 0.