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. 2010 Nov 10;5:49. doi: 10.1186/1750-1326-5-49

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Copyright ©2010 Kwak et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure.7 — Down regulation of PTEN is neuroprotective in acute experimental models. (A) and (B) Downregulation of PTEN with specific siRNA confers neuroprotection 24 h after Aβ exposure (25 μM): PTEN IHC staining (red, A) and MAP/NeuN staining for neuron morphology (green, B). (C) Reduced PTEN protein level in PTEN heterozygous mouse brain (frontal region), accompanied by elevated P-Akt level (2-month-old mice, n = 2). (D) Primary cultured cortical neurons from PTEN +/- pups manifest less apoptotic cell death than PTEN+/+ neurons 24 h after Aβ exposure. Data presented as means ± SD from 5 independent experiments.