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. Author manuscript; available in PMC: 2010 Nov 29.
Published in final edited form as: Neuropsychopharmacology. 2007 Mar 14;32(12):2601–2610. doi: 10.1038/sj.npp.1301382

Fig 1. Experiment 1: A two-week administration of SR 48692 during the withdrawal period attenuates expression of horizontal locomotor sensitization in cocaine preexposed rats.

Fig 1

Rats (n= 40) received cocaine injections (15 mg/kg, i.p.) on days 1, 3, 5, 7 and 14. Daily administration of SR 48692 (1 mg/kg, i.p., n= 20) or vehicle (n=20) was performed from day 15 to day 28. Cocaine challenges (15 mg/kg, i.p.) were performed on days 21 and 28. Data represent mean ± SEM of crossovers summed either over 5 min (A, C, D) or over the 60-min period following cocaine injection (B, C inset, D inset). B: #: P<0.05, ###: P<0.001 vs day 1 (one-way ANOVA, Newman-Keuls). D: **: P<0.01, ***: P<0.001 vs vehicle-treated rats (Two-way ANOVA, Newman-Keuls). D inset: $: P<0.05 vs vehicle-treated rats (Student t-test).