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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Neurobiol Aging. 2010 Aug 19;33(6):1085–1095. doi: 10.1016/j.neurobiolaging.2010.07.002

Figure 2.

Figure 2

The amplitude of the sIAHP increases significantly with age in layer 3 pyramidal cells. A) sIAHPs evoked by increasing depolarizing voltage steps in representative cells from young (left), aged-unimpaired (middle) and aged-impaired monkeys (right). B) Significant positive correlation between sIAHP amplitude and age in all monkeys (left) and those within the aged cohort only (right). Additionally, a U-shaped quadratic equation was fit to the data obtained from all monkeys, and a significant relationship observed (dashed line). C) Line graph plotting mean sIAHP amplitude as a function of voltage step for cells from young, aged-unimpaired and aged-impaired monkeys. Inset: superimposed traces of sIAHPs evoked by +20 mV prepulses in cells from young, aged-unimpaired and aged-impaired monkeys. D) Mean sIAHP amplitude vs. firing rate evoked by a +180 pA 2 s current step. Linear regression line demonstrates no significant relationship between sIAHP amplitude and firing rate. Scale bars: 50 pA/100 ms. * p < 0.01; ** p < 0.001.