Figure 5.
Relationship of sIAHP amplitude to performance on Delayed Non-Match to Sample behavioral tasks. Mean sIAHP amplitude in layer 3 pyramidal cells from a given monkey vs. the monkey’s performance on (A) DNMS basic, (B) DNMS 2 minute delay, and (C) DNMS 10 minute delay. Top: data from all monkeys, bottom: data from aged monkeys only. Bar graphs depicting mean sIAHP amplitude in layer 3 pyramidal cells from young monkeys and aged monkeys that were either unimpaired or impaired on (D) DNMS basic, (E) DNMS 2 minute delay, or (F) DNMS 10 minute delay. Note that because all aged monkeys were impaired on the DNMS 10 minute delay task there is no aged-unimpaired group. Dashed lines in A, B and C correspond to the level above which (DNMS errors) or below which (DNMS 2 and 10 minute delay) a subject is considered significantly impaired. * p < 0.05; ** p < 0.01; *** p < 0.001.
