Table 3.
Characteristics among 1388 non-diabetic adults in the ARIC CAR–MRI studya
| Lactate quartile units |
|||||||
|---|---|---|---|---|---|---|---|
| Characteristic | Overall (n = 1388) | <5.9 (n = 335) | 5.9–7.2 (n = 409) | 7.3–9.1 (n = 367) | ≥9.2 (n=277) | Ptrendb | Ptrend adjustedc |
| Age (years) | 70.2 (69.9–70.6) | 70.1 (69.3–70.8) | 70.4 (69.7–71.1) | 70.1 (69.4–70.8) | 70.3 (69.5–71.1) | 0.791 | 0.528 |
| Female (%) | 57 | 63 | 52 | 59 | 55 | 0.287 | 0.678 |
| African American (%) | 16 | 9 | 18 | 16 | 24 | <0.0001 | 0.002 |
| BMI (kg/m2) | 28.3 (28.0–28.6) | 27.4 (26.8–28.1) | 28.2 (27.6–28.8) | 28.3 (27.8–28.8) | 29.6 (28.8–30.4) | <0.0001 | – |
| Obese (≥30 kg/m2) (%) | 31 | 26 | 30 | 31 | 42 | 0.001 | – |
| Waist circumference (cm) | 99.3 (98.4–100.2) | 95.8 (94.0–97.6) | 99.7 (98.0–101.4) | 99.6 (98.1–101.2) | 102.8 (100.5–105.1) | <0.0001 | – |
| Triglycerides | 127 [92–177] | 107 [82.5–147] | 120 [89–164] | 138 [101–181] | 161 [107–218] | <0.0001 | <0.0001 |
| HDL cholesterol (mg/dl) | 51.5 (50.4–52.5) | 54.3 (52.4–56.3) | 50.9 (49.0–52.7) | 50.5 (48.6–52.4) | 49.9 (47.4–52.4) | 0.011 | 0.278 |
| Trig/HDL ratio | 2.60 [1.68–3.97] | 1.97 [1.39–3.10] | 2.49 [1.59–3.64] | 2.95 [1.87–4.18] | 3.35 [2.10–5.07] | <0.0001 | <0.0001 |
| Trig/HDL r: ≥3 (%) | 42 | 27 | 37 | 50 | 57 | <0.0001 | <0.0001 |
| Trig/HDL r: ≥3/≥2 (%) | 46 | 29 | 43 | 53 | 63 | <0.0001 | <0.0001 |
| Glucose (mg/dl) | 99.8 (99.1–100.5) | 97.2 (95.8–98.6) | 100.0 (98.6–101.4) | 100.8 (99.5–102.1) | 101.5 (99.8–103.3) | <0.0001 | 0.010 |
Trig: Triglyceride.
aResults displayed as percentages, means (95% CIs) and medians [IQRs].
bPtrend takes into account sampling weights for both categorical and continuous variables. Survey-weighted logistic and linear regression were utilized, treating the variable of interest as the dependent variable and the median lactate values by quartile as a continuous independent variable.
cPtrend after adjustment for BMI and waist circumference.